Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359134
(US10220048, Compound AA44 | US10952992, No. AA44 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CNC(=O)OC |r| Show InChI InChI=1S/C17H22N4O6S2/c1-3-12-10-28-16(19-12)14(20-15(22)9-18-17(23)27-2)8-11-4-6-13(7-5-11)21-29(24,25)26/h4-7,10,14,21H,3,8-9H2,1-2H3,(H,18,23)(H,20,22)(H,24,25,26)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359134
(US10220048, Compound AA44 | US10952992, No. AA44 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CNC(=O)OC |r| Show InChI InChI=1S/C17H22N4O6S2/c1-3-12-10-28-16(19-12)14(20-15(22)9-18-17(23)27-2)8-11-4-6-13(7-5-11)21-29(24,25)26/h4-7,10,14,21H,3,8-9H2,1-2H3,(H,18,23)(H,20,22)(H,24,25,26)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359134
(US10220048, Compound AA44 | US10952992, No. AA44 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CNC(=O)OC |r| Show InChI InChI=1S/C17H22N4O6S2/c1-3-12-10-28-16(19-12)14(20-15(22)9-18-17(23)27-2)8-11-4-6-13(7-5-11)21-29(24,25)26/h4-7,10,14,21H,3,8-9H2,1-2H3,(H,18,23)(H,20,22)(H,24,25,26)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359134
(US10220048, Compound AA44 | US10952992, No. AA44 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)CNC(=O)OC |r| Show InChI InChI=1S/C17H22N4O6S2/c1-3-12-10-28-16(19-12)14(20-15(22)9-18-17(23)27-2)8-11-4-6-13(7-5-11)21-29(24,25)26/h4-7,10,14,21H,3,8-9H2,1-2H3,(H,18,23)(H,20,22)(H,24,25,26)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |