Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3/Guanine nucleotide-binding protein subunit alpha-15
(Homo sapiens (Human)) | BDBM208679
(US9266876, 146)Show SMILES CCc1nc(-c2nc3ccccc3[nH]2)c(s1)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12 Show InChI InChI=1S/C25H26N8OS/c1-3-20-30-22(23-28-17-7-4-5-8-18(17)29-23)25(35-20)31-11-12-33(16(2)13-31)21(34)14-32-15-27-19-9-6-10-26-24(19)32/h4-10,15-16H,3,11-14H2,1-2H3,(H,28,29)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the... |
US Patent US9266876 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80NB |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208679
(US9266876, 146)Show SMILES CCc1nc(-c2nc3ccccc3[nH]2)c(s1)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12 Show InChI InChI=1S/C25H26N8OS/c1-3-20-30-22(23-28-17-7-4-5-8-18(17)29-23)25(35-20)31-11-12-33(16(2)13-31)21(34)14-32-15-27-19-9-6-10-26-24(19)32/h4-10,15-16H,3,11-14H2,1-2H3,(H,28,29)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208679
(US9266876, 146)Show SMILES CCc1nc(-c2nc3ccccc3[nH]2)c(s1)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12 Show InChI InChI=1S/C25H26N8OS/c1-3-20-30-22(23-28-17-7-4-5-8-18(17)29-23)25(35-20)31-11-12-33(16(2)13-31)21(34)14-32-15-27-19-9-6-10-26-24(19)32/h4-10,15-16H,3,11-14H2,1-2H3,(H,28,29)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 561 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208679
(US9266876, 146)Show SMILES CCc1nc(-c2nc3ccccc3[nH]2)c(s1)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12 Show InChI InChI=1S/C25H26N8OS/c1-3-20-30-22(23-28-17-7-4-5-8-18(17)29-23)25(35-20)31-11-12-33(16(2)13-31)21(34)14-32-15-27-19-9-6-10-26-24(19)32/h4-10,15-16H,3,11-14H2,1-2H3,(H,28,29)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 862 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM208679
(US9266876, 146)Show SMILES CCc1nc(-c2nc3ccccc3[nH]2)c(s1)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12 Show InChI InChI=1S/C25H26N8OS/c1-3-20-30-22(23-28-17-7-4-5-8-18(17)29-23)25(35-20)31-11-12-33(16(2)13-31)21(34)14-32-15-27-19-9-6-10-26-24(19)32/h4-10,15-16H,3,11-14H2,1-2H3,(H,28,29)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |