Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM103764
(US8551978, I-33 | US8816088, I-33 | US9394275, I-3...)Show SMILES CN(C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1cc(ccc1C)C(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 |r| Show InChI InChI=1S/C49H52N6O7/c1-32-15-16-35(48(60)51-36-12-8-9-33(29-36)21-25-50-31-44(57)39-17-19-43(56)47-40(39)18-20-45(58)53-47)30-42(32)54(2)46(59)24-28-55-26-22-37(23-27-55)62-49(61)52-41-14-7-6-13-38(41)34-10-4-3-5-11-34/h3-20,29-30,37,44,50,56-57H,21-28,31H2,1-2H3,(H,51,60)(H,52,61)(H,53,58)/t44-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance, Inc.
US Patent
| Assay Description Radioligand binding assay using muscarinic receptors. |
US Patent US8551978 (2013)
BindingDB Entry DOI: 10.7270/Q2Q81BPC |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM103764
(US8551978, I-33 | US8816088, I-33 | US9394275, I-3...)Show SMILES CN(C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1cc(ccc1C)C(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 |r| Show InChI InChI=1S/C49H52N6O7/c1-32-15-16-35(48(60)51-36-12-8-9-33(29-36)21-25-50-31-44(57)39-17-19-43(56)47-40(39)18-20-45(58)53-47)30-42(32)54(2)46(59)24-28-55-26-22-37(23-27-55)62-49(61)52-41-14-7-6-13-38(41)34-10-4-3-5-11-34/h3-20,29-30,37,44,50,56-57H,21-28,31H2,1-2H3,(H,51,60)(H,52,61)(H,53,58)/t44-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Respiratory Company, LLC
US Patent
| Assay Description Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 uL. CHO cell me... |
US Patent US8816088 (2014)
BindingDB Entry DOI: 10.7270/Q2TQ6068 |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM103764
(US8551978, I-33 | US8816088, I-33 | US9394275, I-3...)Show SMILES CN(C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1cc(ccc1C)C(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 |r| Show InChI InChI=1S/C49H52N6O7/c1-32-15-16-35(48(60)51-36-12-8-9-33(29-36)21-25-50-31-44(57)39-17-19-43(56)47-40(39)18-20-45(58)53-47)30-42(32)54(2)46(59)24-28-55-26-22-37(23-27-55)62-49(61)52-41-14-7-6-13-38(41)34-10-4-3-5-11-34/h3-20,29-30,37,44,50,56-57H,21-28,31H2,1-2H3,(H,51,60)(H,52,61)(H,53,58)/t44-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 0.200 | -57.6 | n/a | n/a | n/a | n/a | n/a | n/a | 37 |
Theravance Respiratory Company, LLC
US Patent
| Assay Description Displacement assays for determination of Ki values of test compounds were performed with [3H]-NMS at 1 nM and eleven different test compound concentr... |
US Patent US9394275 (2016)
BindingDB Entry DOI: 10.7270/Q2NS0SS8 |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM103764
(US8551978, I-33 | US8816088, I-33 | US9394275, I-3...)Show SMILES CN(C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1cc(ccc1C)C(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 |r| Show InChI InChI=1S/C49H52N6O7/c1-32-15-16-35(48(60)51-36-12-8-9-33(29-36)21-25-50-31-44(57)39-17-19-43(56)47-40(39)18-20-45(58)53-47)30-42(32)54(2)46(59)24-28-55-26-22-37(23-27-55)62-49(61)52-41-14-7-6-13-38(41)34-10-4-3-5-11-34/h3-20,29-30,37,44,50,56-57H,21-28,31H2,1-2H3,(H,51,60)(H,52,61)(H,53,58)/t44-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Respiratory Company LLC
US Patent
| Assay Description compounds were performed with [3H]NMS at 1 nM and eleven different test compound concentrations. The test compounds were initially dissolved to a con... |
US Patent US9572802 (2017)
BindingDB Entry DOI: 10.7270/Q2VH5QWS |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM103764
(US8551978, I-33 | US8816088, I-33 | US9394275, I-3...)Show SMILES CN(C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1cc(ccc1C)C(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 |r| Show InChI InChI=1S/C49H52N6O7/c1-32-15-16-35(48(60)51-36-12-8-9-33(29-36)21-25-50-31-44(57)39-17-19-43(56)47-40(39)18-20-45(58)53-47)30-42(32)54(2)46(59)24-28-55-26-22-37(23-27-55)62-49(61)52-41-14-7-6-13-38(41)34-10-4-3-5-11-34/h3-20,29-30,37,44,50,56-57H,21-28,31H2,1-2H3,(H,51,60)(H,52,61)(H,53,58)/t44-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Respiratory Company, LLC
US Patent
| Assay Description Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 μL. CHO ce... |
US Patent US9682957 (2017)
BindingDB Entry DOI: 10.7270/Q23776WR |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM103764
(US8551978, I-33 | US8816088, I-33 | US9394275, I-3...)Show SMILES CN(C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1cc(ccc1C)C(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 |r| Show InChI InChI=1S/C49H52N6O7/c1-32-15-16-35(48(60)51-36-12-8-9-33(29-36)21-25-50-31-44(57)39-17-19-43(56)47-40(39)18-20-45(58)53-47)30-42(32)54(2)46(59)24-28-55-26-22-37(23-27-55)62-49(61)52-41-14-7-6-13-38(41)34-10-4-3-5-11-34/h3-20,29-30,37,44,50,56-57H,21-28,31H2,1-2H3,(H,51,60)(H,52,61)(H,53,58)/t44-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 25 |
Theravance Respiratory Company, LLC
US Patent
| Assay Description cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P... |
US Patent US9682957 (2017)
BindingDB Entry DOI: 10.7270/Q23776WR |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM103764
(US8551978, I-33 | US8816088, I-33 | US9394275, I-3...)Show SMILES CN(C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)c1cc(ccc1C)C(=O)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 |r| Show InChI InChI=1S/C49H52N6O7/c1-32-15-16-35(48(60)51-36-12-8-9-33(29-36)21-25-50-31-44(57)39-17-19-43(56)47-40(39)18-20-45(58)53-47)30-42(32)54(2)46(59)24-28-55-26-22-37(23-27-55)62-49(61)52-41-14-7-6-13-38(41)34-10-4-3-5-11-34/h3-20,29-30,37,44,50,56-57H,21-28,31H2,1-2H3,(H,51,60)(H,52,61)(H,53,58)/t44-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 37 |
Theravance Respiratory Company, LLC
US Patent
| Assay Description cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P... |
US Patent US9394275 (2016)
BindingDB Entry DOI: 10.7270/Q2NS0SS8 |
More data for this Ligand-Target Pair | |