Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 368.4 BDBM363958

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM363958 (2-[[3-(4-aminopyrido[3,2-d]pyrimidin-6-yl)-5-fluor...) Show SMILES CN(C)C(=O)CN(C)Cc1cc(F)cc(c1)-c1ccc2ncnc(N)c2n1 Show InChI InChI=1S/C19H21FN6O/c1-25(2)17(27)10-26(3)9-12-6-13(8-14(20)7-12)15-4-5-16-18(24-15)19(21)23-11-22-16/h4-8,11H,9-10H2,1-3H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
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