Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM147106
(US8957074, 147)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN4CCC[C@@H]4C3=O)nc2n1C1CCCC1 |r| Show InChI InChI=1S/C26H32N8O2/c1-31(2)24(35)21-14-17-15-28-26(30-23(17)34(21)18-6-3-4-7-18)29-22-10-9-19(16-27-22)33-13-12-32-11-5-8-20(32)25(33)36/h9-10,14-16,18,20H,3-8,11-13H2,1-2H3,(H,27,28,29,30)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novartis AG
US Patent
| Assay Description
An assay for monitoring CDK4/cyclin D1-catalyzed phosphorylation of pRb at the Ser780 site was performed using TR-FRET in a 384-well format, and was ... |
US Patent US8957074 (2015)
BindingDB Entry DOI: 10.7270/Q2K0730S |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM147076
(US8957074, 116)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN4CCCC4C3=O)nc2n1C1CCCC1 Show InChI InChI=1S/C26H32N8O2/c1-31(2)24(35)21-14-17-15-28-26(30-23(17)34(21)18-6-3-4-7-18)29-22-10-9-19(16-27-22)33-13-12-32-11-5-8-20(32)25(33)36/h9-10,14-16,18,20H,3-8,11-13H2,1-2H3,(H,27,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novartis AG
US Patent
| Assay Description
An assay for monitoring CDK4/cyclin D1-catalyzed phosphorylation of pRb at the Ser780 site was performed using TR-FRET in a 384-well format, and was ... |
US Patent US8957074 (2015)
BindingDB Entry DOI: 10.7270/Q2K0730S |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM147105
(US8957074, 146)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN4CCC[C@H]4C3=O)nc2n1C1CCCC1 |r| Show InChI InChI=1S/C26H32N8O2/c1-31(2)24(35)21-14-17-15-28-26(30-23(17)34(21)18-6-3-4-7-18)29-22-10-9-19(16-27-22)33-13-12-32-11-5-8-20(32)25(33)36/h9-10,14-16,18,20H,3-8,11-13H2,1-2H3,(H,27,28,29,30)/t20-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 619 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novartis AG
US Patent
| Assay Description
An assay for monitoring CDK4/cyclin D1-catalyzed phosphorylation of pRb at the Ser780 site was performed using TR-FRET in a 384-well format, and was ... |
US Patent US8957074 (2015)
BindingDB Entry DOI: 10.7270/Q2K0730S |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM147106
(US8957074, 147)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN4CCC[C@@H]4C3=O)nc2n1C1CCCC1 |r| Show InChI InChI=1S/C26H32N8O2/c1-31(2)24(35)21-14-17-15-28-26(30-23(17)34(21)18-6-3-4-7-18)29-22-10-9-19(16-27-22)33-13-12-32-11-5-8-20(32)25(33)36/h9-10,14-16,18,20H,3-8,11-13H2,1-2H3,(H,27,28,29,30)/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
A 384-well microtiter IMAP-FP (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The s... |
US Patent US8957074 (2015)
BindingDB Entry DOI: 10.7270/Q2K0730S |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM147076
(US8957074, 116)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN4CCCC4C3=O)nc2n1C1CCCC1 Show InChI InChI=1S/C26H32N8O2/c1-31(2)24(35)21-14-17-15-28-26(30-23(17)34(21)18-6-3-4-7-18)29-22-10-9-19(16-27-22)33-13-12-32-11-5-8-20(32)25(33)36/h9-10,14-16,18,20H,3-8,11-13H2,1-2H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
A 384-well microtiter IMAP-FP (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The s... |
US Patent US8957074 (2015)
BindingDB Entry DOI: 10.7270/Q2K0730S |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM147105
(US8957074, 146)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN4CCC[C@H]4C3=O)nc2n1C1CCCC1 |r| Show InChI InChI=1S/C26H32N8O2/c1-31(2)24(35)21-14-17-15-28-26(30-23(17)34(21)18-6-3-4-7-18)29-22-10-9-19(16-27-22)33-13-12-32-11-5-8-20(32)25(33)36/h9-10,14-16,18,20H,3-8,11-13H2,1-2H3,(H,27,28,29,30)/t20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
A 384-well microtiter IMAP-FP (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The s... |
US Patent US8957074 (2015)
BindingDB Entry DOI: 10.7270/Q2K0730S |
More data for this
Ligand-Target Pair | |