Found 17 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Chromatin remodeling regulator CECR2
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Chromatin remodeling regulator CECR2
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 9
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 9
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1 [1504-1635]
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
US Patent
| Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ... |
US Patent US10183009 (2019)
BindingDB Entry DOI: 10.7270/Q2125VRQ |
More data for this
Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
CREB-binding protein
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Peregrin
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Peregrin
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
CREB-binding protein
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM321443
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay |
J Med Chem 59: 5391-402 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641 |
More data for this
Ligand-Target Pair | |