Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 452.5 BDBM84539

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM84539 (Indirubin derivative, 36 (X=O)) Show SMILES CN(C)C1CCN(CC1)S(=O)(=O)c1ccc2NC(=O)C(=C3Nc4ccccc4C3=O)c2c1 |w:20.30| Show InChI InChI=1S/C23H24N4O4S/c1-26(2)14-9-11-27(12-10-14)32(30,31)15-7-8-19-17(13-15)20(23(29)25-19)21-22(28)16-5-3-4-6-18(16)24-21/h3-8,13-14,24H,9-12H2,1-2H3,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	8.0	22
Schering AG					Assay Description Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.				Chembiochem 6: 531-40 (2005) Article DOI: 10.1002/cbic.200400108 BindingDB Entry DOI: 10.7270/Q2B56H8H
					More data for this Ligand-Target Pair