Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386041
(4-(4-(2-(dimethylamino)-1-(o-tolyl)ethyl)piperazin...)Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccccc1C Show InChI InChI=1S/C21H29N7O/c1-15-6-4-5-7-16(15)17(13-26(2)3)27-8-10-28(11-9-27)21-19-20(23-14-24-21)22-12-18(29)25-19/h4-7,14,17H,8-13H2,1-3H3,(H,25,29)(H,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386041
(4-(4-(2-(dimethylamino)-1-(o-tolyl)ethyl)piperazin...)Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccccc1C Show InChI InChI=1S/C21H29N7O/c1-15-6-4-5-7-16(15)17(13-26(2)3)27-8-10-28(11-9-27)21-19-20(23-14-24-21)22-12-18(29)25-19/h4-7,14,17H,8-13H2,1-3H3,(H,25,29)(H,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |