Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386015
(US10287300, Compound A21 | [2-[4-(6,7-Dihydro-5H-p...)Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(c(F)c1)C(F)(F)F Show InChI InChI=1S/C21H26F4N6/c1-29(2)12-18(14-3-4-16(17(22)11-14)21(23,24)25)30-7-9-31(10-8-30)20-15-5-6-26-19(15)27-13-28-20/h3-4,11,13,18H,5-10,12H2,1-2H3,(H,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386015
(US10287300, Compound A21 | [2-[4-(6,7-Dihydro-5H-p...)Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(c(F)c1)C(F)(F)F Show InChI InChI=1S/C21H26F4N6/c1-29(2)12-18(14-3-4-16(17(22)11-14)21(23,24)25)30-7-9-31(10-8-30)20-15-5-6-26-19(15)27-13-28-20/h3-4,11,13,18H,5-10,12H2,1-2H3,(H,26,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |