Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health
US Patent
| Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... |
US Patent US9682983 (2017)
BindingDB Entry DOI: 10.7270/Q28S4N3R |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc.
US Patent
| Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... |
US Patent US10017516 (2018)
BindingDB Entry DOI: 10.7270/Q20P12CN |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc.
US Patent
| Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... |
US Patent US10017516 (2018)
BindingDB Entry DOI: 10.7270/Q20P12CN |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health
US Patent
| Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... |
US Patent US9682983 (2017)
BindingDB Entry DOI: 10.7270/Q28S4N3R |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc.
US Patent
| Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... |
US Patent US10017516 (2018)
BindingDB Entry DOI: 10.7270/Q20P12CN |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.97E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health
US Patent
| Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... |
US Patent US9682983 (2017)
BindingDB Entry DOI: 10.7270/Q28S4N3R |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc.
US Patent
| Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... |
US Patent US10017516 (2018)
BindingDB Entry DOI: 10.7270/Q20P12CN |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A
(Homo sapiens (Human)) | BDBM148329
(US10017516, Compound 19 | US9682983, 19)Show SMILES CN(C)Cc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C28H29N7/c1-33(2)18-20-3-8-25-24(9-10-30-27(25)15-20)26-17-32-35-19-22(16-31-28(26)35)21-4-6-23(7-5-21)34-13-11-29-12-14-34/h3-10,15-17,19,29H,11-14,18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.28E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health
US Patent
| Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... |
US Patent US9682983 (2017)
BindingDB Entry DOI: 10.7270/Q28S4N3R |
More data for this Ligand-Target Pair | |