Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338135
(US9751854, Compound I-311 | US9802960, Compound I-...)Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C17H21N5O3S/c1-11-15(21-26(24,25)22(2)3)8-14(10-19-11)13-6-7-18-16(9-13)20-17(23)12-4-5-12/h6-10,12,21H,4-5H2,1-3H3,(H,18,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description 100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9802960 (2017)
BindingDB Entry DOI: 10.7270/Q2D79DJ9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338135
(US9751854, Compound I-311 | US9802960, Compound I-...)Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C17H21N5O3S/c1-11-15(21-26(24,25)22(2)3)8-14(10-19-11)13-6-7-18-16(9-13)20-17(23)12-4-5-12/h6-10,12,21H,4-5H2,1-3H3,(H,18,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description 100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9751854 (2017)
BindingDB Entry DOI: 10.7270/Q2KS6TNJ |
More data for this Ligand-Target Pair | |