Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50045848
(CHEMBL3309948)Show SMILES CN(C)c1ccc(\C=C2/CNC\C(=C/c3ccc(cc3[N+]([O-])=O)N(C)C)C2=O)c(c1)[N+]([O-])=O Show InChI InChI=1S/C23H25N5O5/c1-25(2)19-7-5-15(21(11-19)27(30)31)9-17-13-24-14-18(23(17)29)10-16-6-8-20(26(3)4)12-22(16)28(32)33/h5-12,24H,13-14H2,1-4H3/b17-9+,18-10+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Universiti Kebangsaan Malaysia
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins |
Bioorg Med Chem 22: 4151-61 (2014)
Article DOI: 10.1016/j.bmc.2014.05.052 BindingDB Entry DOI: 10.7270/Q2GX4D6F |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50045848
(CHEMBL3309948)Show SMILES CN(C)c1ccc(\C=C2/CNC\C(=C/c3ccc(cc3[N+]([O-])=O)N(C)C)C2=O)c(c1)[N+]([O-])=O Show InChI InChI=1S/C23H25N5O5/c1-25(2)19-7-5-15(21(11-19)27(30)31)9-17-13-24-14-18(23(17)29)10-16-6-8-20(26(3)4)12-22(16)28(32)33/h5-12,24H,13-14H2,1-4H3/b17-9+,18-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universiti Kebangsaan Malaysia
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins |
Bioorg Med Chem 22: 4151-61 (2014)
Article DOI: 10.1016/j.bmc.2014.05.052 BindingDB Entry DOI: 10.7270/Q2GX4D6F |
More data for this Ligand-Target Pair | |
Lipoxygenase
(Glycine max) | BDBM50045848
(CHEMBL3309948)Show SMILES CN(C)c1ccc(\C=C2/CNC\C(=C/c3ccc(cc3[N+]([O-])=O)N(C)C)C2=O)c(c1)[N+]([O-])=O Show InChI InChI=1S/C23H25N5O5/c1-25(2)19-7-5-15(21(11-19)27(30)31)9-17-13-24-14-18(23(17)29)10-16-6-8-20(26(3)4)12-22(16)28(32)33/h5-12,24H,13-14H2,1-4H3/b17-9+,18-10+ | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universiti Kebangsaan Malaysia
Curated by ChEMBL
| Assay Description Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay |
Bioorg Med Chem 22: 4151-61 (2014)
Article DOI: 10.1016/j.bmc.2014.05.052 BindingDB Entry DOI: 10.7270/Q2GX4D6F |
More data for this Ligand-Target Pair | |