Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50177075
(3-Cyclohexylmethyl-9-dimethylamino-3H-pyrido[3',2'...)Show InChI InChI=1S/C18H22N4OS/c1-21(2)13-8-9-19-17-14(13)15-16(24-17)18(23)22(11-20-15)10-12-6-4-3-5-7-12/h8-9,11-12H,3-7,10H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization |
J Med Chem 48: 7374-88 (2005)
Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50177075
(3-Cyclohexylmethyl-9-dimethylamino-3H-pyrido[3',2'...)Show InChI InChI=1S/C18H22N4OS/c1-21(2)13-8-9-19-17-14(13)15-16(24-17)18(23)22(11-20-15)10-12-6-4-3-5-7-12/h8-9,11-12H,3-7,10H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocampus
Curated by ChEMBL
| Assay Description Inhibition of rat mGluR1 |
Eur J Med Chem 43: 1025-34 (2008)
Article DOI: 10.1016/j.ejmech.2007.06.024 BindingDB Entry DOI: 10.7270/Q2V987VM |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50177075
(3-Cyclohexylmethyl-9-dimethylamino-3H-pyrido[3',2'...)Show InChI InChI=1S/C18H22N4OS/c1-21(2)13-8-9-19-17-14(13)15-16(24-17)18(23)22(11-20-15)10-12-6-4-3-5-7-12/h8-9,11-12H,3-7,10H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization |
J Med Chem 48: 7374-88 (2005)
Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0 |
More data for this Ligand-Target Pair | |