Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM183015
(US9150544, 49)Show SMILES CN(C1CCC1)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O |r| Show InChI InChI=1S/C24H27ClN6O5S2/c1-30(15-3-2-4-15)24-28-12-20(37-24)38(35,36)29-18-6-8-31(22(18)32)19(23(33)34)10-14-9-13-5-7-27-21(26)16(13)11-17(14)25/h5,7,9,11-12,15,18-19,29H,2-4,6,8,10H2,1H3,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
US Patent
| Assay Description The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 µM final) and deposited in a proportion of 25 µl per we... |
US Patent US9150544 (2015)
BindingDB Entry DOI: 10.7270/Q27S7MKF |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM183015
(US9150544, 49)Show SMILES CN(C1CCC1)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O |r| Show InChI InChI=1S/C24H27ClN6O5S2/c1-30(15-3-2-4-15)24-28-12-20(37-24)38(35,36)29-18-6-8-31(22(18)32)19(23(33)34)10-14-9-13-5-7-27-21(26)16(13)11-17(14)25/h5,7,9,11-12,15,18-19,29H,2-4,6,8,10H2,1H3,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Sanofi
US Patent
| Assay Description The compounds according to the invention are tested in a range of concentrations (10pM to 10 µM final) in assay buffer (50 mM TRIS, 100 mM NaCl, 0.1 ... |
US Patent US9150544 (2015)
BindingDB Entry DOI: 10.7270/Q27S7MKF |
More data for this Ligand-Target Pair | |