Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 624.0 BDBM104816

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysosomal Pro-X carboxypeptidase (Homo sapiens (Human))	BDBM104816 (US8569299, 2) Show SMILES CN(CCC(F)(F)F)[C@@H]1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCC(CC1)c1nc(C)nn1-c1ccc(Cl)c(C)c1 |r| Show InChI InChI=1S/C31H35ClF5N5O/c1-18-14-22(5-7-27(18)32)42-29(38-19(2)39-42)20-8-11-41(12-9-20)30(43)26-17-23(40(3)13-10-31(35,36)37)16-25(26)24-6-4-21(33)15-28(24)34/h4-7,14-15,20,23,25-26H,8-13,16-17H2,1-3H3/t23-,25-,26+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	5.5	37
Merck Sharp & Dohme Corp US Patent					Assay Description The potency of compounds against PRCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PRCP inhibitor test compo...				US Patent US8569299 (2013) BindingDB Entry DOI: 10.7270/Q2K9365V
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