Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50251387
(2-(Methyl-{3-[methyl-(4-sulfamoyl-benzyl)-amino]-p...)Show SMILES CN(CCCN(C)Cc1ccc(cc1)S(N)(=O)=O)CC(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H32N4O4S/c1-29(19-21-9-15-25(16-10-21)35(27,32)33)17-6-18-30(2)20-26(31)28-22-11-13-24(14-12-22)34-23-7-4-3-5-8-23/h3-5,7-16H,6,17-20H2,1-2H3,(H,28,31)(H2,27,32,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences
Curated by ChEMBL
| Assay Description Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay |
Bioorg Med Chem Lett 18: 3891-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.046 BindingDB Entry DOI: 10.7270/Q20P0ZTV |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50251387
(2-(Methyl-{3-[methyl-(4-sulfamoyl-benzyl)-amino]-p...)Show SMILES CN(CCCN(C)Cc1ccc(cc1)S(N)(=O)=O)CC(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H32N4O4S/c1-29(19-21-9-15-25(16-10-21)35(27,32)33)17-6-18-30(2)20-26(31)28-22-11-13-24(14-12-22)34-23-7-4-3-5-8-23/h3-5,7-16H,6,17-20H2,1-2H3,(H,28,31)(H2,27,32,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University (GNU)
Curated by ChEMBL
| Assay Description Inhibition of human leukotriene A4 hydrolase |
Eur J Med Chem 46: 1593-603 (2011)
Article DOI: 10.1016/j.ejmech.2011.02.007 BindingDB Entry DOI: 10.7270/Q2K64JDG |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50251387
(2-(Methyl-{3-[methyl-(4-sulfamoyl-benzyl)-amino]-p...)Show SMILES CN(CCCN(C)Cc1ccc(cc1)S(N)(=O)=O)CC(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H32N4O4S/c1-29(19-21-9-15-25(16-10-21)35(27,32)33)17-6-18-30(2)20-26(31)28-22-11-13-24(14-12-22)34-23-7-4-3-5-8-23/h3-5,7-16H,6,17-20H2,1-2H3,(H,28,31)(H2,27,32,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences
Curated by ChEMBL
| Assay Description Inhibition of LTA4 hydrolase (unknown origin) by whole blood assay |
Bioorg Med Chem Lett 18: 3891-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.046 BindingDB Entry DOI: 10.7270/Q20P0ZTV |
More data for this Ligand-Target Pair | |