Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM242233
(US9416129, 11)Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1cnco1 |r| Show InChI InChI=1S/C18H17ClN4O3S2/c1-18(9-28(24,25)23(2)17(20)22-18)16-13(19)7-15(27-16)12-5-3-4-11(6-12)14-8-21-10-26-14/h3-8,10H,9H2,1-2H3,(H2,20,22)/t18-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 1.70 | -50.9 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Varying concentrations of inhibitors at 3× the final desired concentration in a volume of 10 μl are preincubated with purified human BACE1 c... |
US Patent US9416129 (2016)
BindingDB Entry DOI: 10.7270/Q2HM57C6 |
More data for this
Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM242233
(US9416129, 11)Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1cnco1 |r| Show InChI InChI=1S/C18H17ClN4O3S2/c1-18(9-28(24,25)23(2)17(20)22-18)16-13(19)7-15(27-16)12-5-3-4-11(6-12)14-8-21-10-26-14/h3-8,10H,9H2,1-2H3,(H2,20,22)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 2 | -50.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... |
US Patent US9416129 (2016)
BindingDB Entry DOI: 10.7270/Q2HM57C6 |
More data for this
Ligand-Target Pair | |