Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM256817
(US9489013, 88)Show SMILES CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(C)(=O)=O)S1(=O)=O |r| Show InChI InChI=1S/C21H24F2N6O5S2/c1-20(15-10-14(5-6-16(15)23)26-18(30)17-7-4-13(22)11-25-17)21(8-9-29(12-21)35(3,31)32)36(33,34)28(2)19(24)27-20/h4-7,10-11H,8-9,12H2,1-3H3,(H2,24,27)(H,26,30)/t20-,21+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 34 | -43.3 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo... |
US Patent US9489013 (2016)
BindingDB Entry DOI: 10.7270/Q2Q81C18 |
More data for this
Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM256817
(US9489013, 88)Show SMILES CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(C)(=O)=O)S1(=O)=O |r| Show InChI InChI=1S/C21H24F2N6O5S2/c1-20(15-10-14(5-6-16(15)23)26-18(30)17-7-4-13(22)11-25-17)21(8-9-29(12-21)35(3,31)32)36(33,34)28(2)19(24)27-20/h4-7,10-11H,8-9,12H2,1-3H3,(H2,24,27)(H,26,30)/t20-,21+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 54 | -42.2 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Inhibitor IC50's at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV... |
US Patent US9489013 (2016)
BindingDB Entry DOI: 10.7270/Q2Q81C18 |
More data for this
Ligand-Target Pair | |