Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM256758
(US9489013, 29)Show SMILES CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3ccncc3)C2)S1(=O)=O |r| Show InChI InChI=1S/C26H27F2N7O3S/c1-25(20-13-19(4-5-21(20)28)32-23(36)22-6-3-18(27)14-31-22)26(39(37,38)34(2)24(29)33-25)9-12-35(16-26)15-17-7-10-30-11-8-17/h3-8,10-11,13-14H,9,12,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 8 | -47.0 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo... |
US Patent US9489013 (2016)
BindingDB Entry DOI: 10.7270/Q2Q81C18 |
More data for this
Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM256758
(US9489013, 29)Show SMILES CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3ccncc3)C2)S1(=O)=O |r| Show InChI InChI=1S/C26H27F2N7O3S/c1-25(20-13-19(4-5-21(20)28)32-23(36)22-6-3-18(27)14-31-22)26(39(37,38)34(2)24(29)33-25)9-12-35(16-26)15-17-7-10-30-11-8-17/h3-8,10-11,13-14H,9,12,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 9 | -46.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Inhibitor IC50's at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV... |
US Patent US9489013 (2016)
BindingDB Entry DOI: 10.7270/Q2Q81C18 |
More data for this
Ligand-Target Pair | |