Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM352263
(US9802928, 1s)Show SMILES CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)C2(CC2)S1(=O)=O |r| Show InChI InChI=1S/C20H20F3N5O4S/c1-19(20(7-8-20)33(30,31)28(2)18(24)27-19)13-9-11(3-5-14(13)21)26-16(29)15-6-4-12(10-25-15)32-17(22)23/h3-6,9-10,17H,7-8H2,1-2H3,(H2,24,27)(H,26,29)/t19-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo... |
US Patent US9802928 (2017)
BindingDB Entry DOI: 10.7270/Q21Z46K6 |
More data for this Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM352263
(US9802928, 1s)Show SMILES CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)C2(CC2)S1(=O)=O |r| Show InChI InChI=1S/C20H20F3N5O4S/c1-19(20(7-8-20)33(30,31)28(2)18(24)27-19)13-9-11(3-5-14(13)21)26-16(29)15-6-4-12(10-25-15)32-17(22)23/h3-6,9-10,17H,7-8H2,1-2H3,(H2,24,27)(H,26,29)/t19-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN... |
US Patent US9802928 (2017)
BindingDB Entry DOI: 10.7270/Q21Z46K6 |
More data for this Ligand-Target Pair | |