Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM501319
(US11021493, Example 238)Show SMILES CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nc(C)oc3C)cn2)cc(F)c1F |r,c:3| Show InChI InChI=1S/C23H23F3N6O4S/c1-12-19(30-13(2)36-12)10-35-20-9-28-18(8-29-20)16(24)6-14-5-15(21(26)17(25)7-14)23(3)11-37(33,34)32(4)22(27)31-23/h5-9H,10-11H2,1-4H3,(H2,27,31)/b16-6-/t23-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM501319
(US11021493, Example 238)Show SMILES CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nc(C)oc3C)cn2)cc(F)c1F |r,c:3| Show InChI InChI=1S/C23H23F3N6O4S/c1-12-19(30-13(2)36-12)10-35-20-9-28-18(8-29-20)16(24)6-14-5-15(21(26)17(25)7-14)23(3)11-37(33,34)32(4)22(27)31-23/h5-9H,10-11H2,1-4H3,(H2,27,31)/b16-6-/t23-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM501319
(US11021493, Example 238)Show SMILES CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nc(C)oc3C)cn2)cc(F)c1F |r,c:3| Show InChI InChI=1S/C23H23F3N6O4S/c1-12-19(30-13(2)36-12)10-35-20-9-28-18(8-29-20)16(24)6-14-5-15(21(26)17(25)7-14)23(3)11-37(33,34)32(4)22(27)31-23/h5-9H,10-11H2,1-4H3,(H2,27,31)/b16-6-/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM501319
(US11021493, Example 238)Show SMILES CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nc(C)oc3C)cn2)cc(F)c1F |r,c:3| Show InChI InChI=1S/C23H23F3N6O4S/c1-12-19(30-13(2)36-12)10-35-20-9-28-18(8-29-20)16(24)6-14-5-15(21(26)17(25)7-14)23(3)11-37(33,34)32(4)22(27)31-23/h5-9H,10-11H2,1-4H3,(H2,27,31)/b16-6-/t23-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |