Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cathepsin S
(Homo sapiens (Human)) | BDBM50273287
(2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrim...)Show SMILES CN1CCC(CC1)(NC(=O)c1cnc(nc1NCC1CCC2(CC2)CC1)C#N)c1ccccc1 Show InChI InChI=1S/C27H34N6O/c1-33-15-13-27(14-16-33,21-5-3-2-4-6-21)32-25(34)22-19-29-23(17-28)31-24(22)30-18-20-7-9-26(10-8-20)11-12-26/h2-6,19-20H,7-16,18H2,1H3,(H,32,34)(H,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin S by fluorometric assay |
Bioorg Med Chem Lett 18: 4642-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.011
BindingDB Entry DOI: 10.7270/Q2WH2PS6 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50273287
(2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrim...)Show SMILES CN1CCC(CC1)(NC(=O)c1cnc(nc1NCC1CCC2(CC2)CC1)C#N)c1ccccc1 Show InChI InChI=1S/C27H34N6O/c1-33-15-13-27(14-16-33,21-5-3-2-4-6-21)32-25(34)22-19-29-23(17-28)31-24(22)30-18-20-7-9-26(10-8-20)11-12-26/h2-6,19-20H,7-16,18H2,1H3,(H,32,34)(H,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin L by fluorometric assay |
Bioorg Med Chem Lett 18: 4642-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.011
BindingDB Entry DOI: 10.7270/Q2WH2PS6 |
More data for this
Ligand-Target Pair | |