Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50383306
(CHEMBL2029618)Show SMILES CN1CCC[C@@H]1c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 |r| Show InChI InChI=1S/C20H19NO4/c1-21-9-5-8-13(21)18-14(22)10-15(23)19-16(24)11-17(25-20(18)19)12-6-3-2-4-7-12/h2-4,6-7,10-11,13,22-23H,5,8-9H2,1H3/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK5/p25 using [gamma 33P]ATP after 30 mins by scintillation counting |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50383306
(CHEMBL2029618)Show SMILES CN1CCC[C@@H]1c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 |r| Show InChI InChI=1S/C20H19NO4/c1-21-9-5-8-13(21)18-14(22)10-15(23)19-16(24)11-17(25-20(18)19)12-6-3-2-4-7-12/h2-4,6-7,10-11,13,22-23H,5,8-9H2,1H3/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK5/p25 using [gamma 33P]ATP after 30 mins by scintillation counting |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Mus musculus) | BDBM50383306
(CHEMBL2029618)Show SMILES CN1CCC[C@@H]1c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 |r| Show InChI InChI=1S/C20H19NO4/c1-21-9-5-8-13(21)18-14(22)10-15(23)19-16(24)11-17(25-20(18)19)12-6-3-2-4-7-12/h2-4,6-7,10-11,13,22-23H,5,8-9H2,1H3/t13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Mus musculus) | BDBM50383306
(CHEMBL2029618)Show SMILES CN1CCC[C@@H]1c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 |r| Show InChI InChI=1S/C20H19NO4/c1-21-9-5-8-13(21)18-14(22)10-15(23)19-16(24)11-17(25-20(18)19)12-6-3-2-4-7-12/h2-4,6-7,10-11,13,22-23H,5,8-9H2,1H3/t13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50383306
(CHEMBL2029618)Show SMILES CN1CCC[C@@H]1c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 |r| Show InChI InChI=1S/C20H19NO4/c1-21-9-5-8-13(21)18-14(22)10-15(23)19-16(24)11-17(25-20(18)19)12-6-3-2-4-7-12/h2-4,6-7,10-11,13,22-23H,5,8-9H2,1H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged rat recombinant DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50383306
(CHEMBL2029618)Show SMILES CN1CCC[C@@H]1c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 |r| Show InChI InChI=1S/C20H19NO4/c1-21-9-5-8-13(21)18-14(22)10-15(23)19-16(24)11-17(25-20(18)19)12-6-3-2-4-7-12/h2-4,6-7,10-11,13,22-23H,5,8-9H2,1H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged rat recombinant DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |