Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM326956
(9-[(S)-4-(2,3-Dihydro- benzo[1,4]dioxin-2-yl)-ben...)Show SMILES CN1CCCC2(CCN(Cc3ccc(cc3)[C@H]3COc4ccccc4O3)CC2)C1=O |r| Show InChI InChI=1S/C25H30N2O3/c1-26-14-4-11-25(24(26)28)12-15-27(16-13-25)17-19-7-9-20(10-8-19)23-18-29-21-5-2-3-6-22(21)30-23/h2-3,5-10,23H,4,11-18H2,1H3/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ... |
US Patent US9662339 (2017)
BindingDB Entry DOI: 10.7270/Q2GT5Q8D |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM326956
(9-[(S)-4-(2,3-Dihydro- benzo[1,4]dioxin-2-yl)-ben...)Show SMILES CN1CCCC2(CCN(Cc3ccc(cc3)[C@H]3COc4ccccc4O3)CC2)C1=O |r| Show InChI InChI=1S/C25H30N2O3/c1-26-14-4-11-25(24(26)28)12-15-27(16-13-25)17-19-7-9-20(10-8-19)23-18-29-21-5-2-3-6-22(21)30-23/h2-3,5-10,23H,4,11-18H2,1H3/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ... |
US Patent US9662339 (2017)
BindingDB Entry DOI: 10.7270/Q2GT5Q8D |
More data for this Ligand-Target Pair | |