Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50170113
(CHEMBL3806043)Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NCc2ccccc2)c1 Show InChI InChI=1S/C33H32F2N6O/c1-40-11-13-41(14-12-40)27-8-9-28(31(20-27)36-21-22-5-3-2-4-6-22)33(42)37-32-29-18-23(7-10-30(29)38-39-32)15-24-16-25(34)19-26(35)17-24/h2-10,16-20,36H,11-15,21H2,1H3,(H2,37,38,39,42) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 378 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
Curated by ChEMBL
| Assay Description Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATP |
J Med Chem 59: 3392-408 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00064 BindingDB Entry DOI: 10.7270/Q27M09TG |
More data for this Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50170113
(CHEMBL3806043)Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NCc2ccccc2)c1 Show InChI InChI=1S/C33H32F2N6O/c1-40-11-13-41(14-12-40)27-8-9-28(31(20-27)36-21-22-5-3-2-4-6-22)33(42)37-32-29-18-23(7-10-30(29)38-39-32)15-24-16-25(34)19-26(35)17-24/h2-10,16-20,36H,11-15,21H2,1H3,(H2,37,38,39,42) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
Curated by ChEMBL
| Assay Description Inhibition of IR (unknown origin) in presence of gamma33-ATP |
J Med Chem 59: 3392-408 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00064 BindingDB Entry DOI: 10.7270/Q27M09TG |
More data for this Ligand-Target Pair | |