Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 532.4 BDBM177064

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM177064 (US9120749, 430) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1 Show InChI InChI=1S/C30H27Cl2N3O2/c1-34-10-12-35(13-11-34)22-7-4-18(5-8-22)28-23-14-20(21-15-25(31)30(37)26(32)16-21)6-9-27(23)33-17-24(28)29(36)19-2-3-19/h4-9,14-17,19,37H,2-3,10-13H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	7.4	25
ONCOTHERAPY SCIENCE, INC. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872
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