Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 575.5 BDBM177463

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM177463 (US9120749, 829) Show SMILES CN1CCN(CCc2cccc(Nc3c(cnc4ccc(cc34)-c3cc(Cl)c(O)c(Cl)c3)C(=O)C3CC3)c2)CC1 Show InChI InChI=1S/C32H32Cl2N4O2/c1-37-11-13-38(14-12-37)10-9-20-3-2-4-24(15-20)36-30-25-16-22(23-17-27(33)32(40)28(34)18-23)7-8-29(25)35-19-26(30)31(39)21-5-6-21/h2-4,7-8,15-19,21,40H,5-6,9-14H2,1H3,(H,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.4	25
ONCOTHERAPY SCIENCE, INC. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872
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