Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 546.4 BDBM177116

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM177116 (US9120749, 482) Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cnc3ccc(cc23)-c2cc(Cl)c(O)c(Cl)c2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C31H29Cl2N3O2/c1-35-10-12-36(13-11-35)18-19-2-4-20(5-3-19)29-24-14-22(23-15-26(32)31(38)27(33)16-23)8-9-28(24)34-17-25(29)30(37)21-6-7-21/h2-5,8-9,14-17,21,38H,6-7,10-13,18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	7.4	25
ONCOTHERAPY SCIENCE, INC. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872
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