Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM50235290
(CHEMBL4068028)Show SMILES CN1CCN(Cc2ccc3ccc(Cl)c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c3c2)CC1 |t:15| Show InChI InChI=1S/C29H27ClN4O2/c1-32-11-13-34(14-12-32)16-18-7-8-19-9-10-23(30)25(21(19)15-18)27-26(28(35)31-29(27)36)22-17-33(2)24-6-4-3-5-20(22)24/h3-10,15,17H,11-14,16H2,1-2H3,(H,31,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Compound was evaluated for binding affinity to Dopamine receptor D2 labeled with [3H]spiroperidol (0.5 nM) in rat striatal membranes |
Bioorg Med Chem Lett 27: 781-786 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1 |
More data for this Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM50235290
(CHEMBL4068028)Show SMILES CN1CCN(Cc2ccc3ccc(Cl)c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c3c2)CC1 |t:15| Show InChI InChI=1S/C29H27ClN4O2/c1-32-11-13-34(14-12-32)16-18-7-8-19-9-10-23(30)25(21(19)15-18)27-26(28(35)31-29(27)36)22-17-33(2)24-6-4-3-5-20(22)24/h3-10,15,17H,11-14,16H2,1-2H3,(H,31,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PKCalpha (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay |
Bioorg Med Chem Lett 27: 781-786 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1 |
More data for this Ligand-Target Pair | |
Protein kinase C epsilon type
(Homo sapiens (Human)) | BDBM50235290
(CHEMBL4068028)Show SMILES CN1CCN(Cc2ccc3ccc(Cl)c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c3c2)CC1 |t:15| Show InChI InChI=1S/C29H27ClN4O2/c1-32-11-13-34(14-12-32)16-18-7-8-19-9-10-23(30)25(21(19)15-18)27-26(28(35)31-29(27)36)22-17-33(2)24-6-4-3-5-20(22)24/h3-10,15,17H,11-14,16H2,1-2H3,(H,31,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PKCepsilon (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay |
Bioorg Med Chem Lett 27: 781-786 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1 |
More data for this Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50235290
(CHEMBL4068028)Show SMILES CN1CCN(Cc2ccc3ccc(Cl)c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c3c2)CC1 |t:15| Show InChI InChI=1S/C29H27ClN4O2/c1-32-11-13-34(14-12-32)16-18-7-8-19-9-10-23(30)25(21(19)15-18)27-26(28(35)31-29(27)36)22-17-33(2)24-6-4-3-5-20(22)24/h3-10,15,17H,11-14,16H2,1-2H3,(H,31,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 292 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PKCdelta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay |
Bioorg Med Chem Lett 27: 781-786 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1 |
More data for this Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50235290
(CHEMBL4068028)Show SMILES CN1CCN(Cc2ccc3ccc(Cl)c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c3c2)CC1 |t:15| Show InChI InChI=1S/C29H27ClN4O2/c1-32-11-13-34(14-12-32)16-18-7-8-19-9-10-23(30)25(21(19)15-18)27-26(28(35)31-29(27)36)22-17-33(2)24-6-4-3-5-20(22)24/h3-10,15,17H,11-14,16H2,1-2H3,(H,31,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 314 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PKCtheta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay |
Bioorg Med Chem Lett 27: 781-786 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1 |
More data for this Ligand-Target Pair | |
Protein kinase C eta type
(Homo sapiens (Human)) | BDBM50235290
(CHEMBL4068028)Show SMILES CN1CCN(Cc2ccc3ccc(Cl)c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c3c2)CC1 |t:15| Show InChI InChI=1S/C29H27ClN4O2/c1-32-11-13-34(14-12-32)16-18-7-8-19-9-10-23(30)25(21(19)15-18)27-26(28(35)31-29(27)36)22-17-33(2)24-6-4-3-5-20(22)24/h3-10,15,17H,11-14,16H2,1-2H3,(H,31,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PKCeta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay |
Bioorg Med Chem Lett 27: 781-786 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1 |
More data for this Ligand-Target Pair | |