Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 389.7 BDBM129163

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM129163 (US8802674, 266) Show SMILES CNC(=O)c1cc(Cl)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1OC Show InChI InChI=1S/C15H15ClF3N5O2/c1-20-12-8(15(17,18)19)6-22-14(24-12)23-10-5-11(26-3)7(4-9(10)16)13(25)21-2/h4-6H,1-3H3,(H,21,25)(H2,20,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...				US Patent US8802674 (2014) BindingDB Entry DOI: 10.7270/Q2GF0S6N
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