Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50443726
(CHEMBL3093883 | US9238658, 12)Show SMILES CNC(=O)c1cccc(NC(=O)N2CCC(CC2)N2CCc3ccccc23)c1 Show InChI InChI=1S/C22H26N4O2/c1-23-21(27)17-6-4-7-18(15-17)24-22(28)25-12-10-19(11-13-25)26-14-9-16-5-2-3-8-20(16)26/h2-8,15,19H,9-14H2,1H3,(H,23,27)(H,24,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generation |
Bioorg Med Chem Lett 23: 6773-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.096 BindingDB Entry DOI: 10.7270/Q21J9C7J |
More data for this Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50443726
(CHEMBL3093883 | US9238658, 12)Show SMILES CNC(=O)c1cccc(NC(=O)N2CCC(CC2)N2CCc3ccccc23)c1 Show InChI InChI=1S/C22H26N4O2/c1-23-21(27)17-6-4-7-18(15-17)24-22(28)25-12-10-19(11-13-25)26-14-9-16-5-2-3-8-20(16)26/h2-8,15,19H,9-14H2,1H3,(H,23,27)(H,24,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| US Patent
| n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Pharmaceutica NV
US Patent
| Assay Description The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac... |
US Patent US9238658 (2016)
BindingDB Entry DOI: 10.7270/Q2930S1D |
More data for this Ligand-Target Pair | |