Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM111805
(2,6-Bis[4-(methylaminoethanol)benzylidine] cyclohe...)Show SMILES CNC(CO)c1ccc(\C=C2/CCC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1 Show InChI InChI=1S/C26H32N2O3/c1-27-24(16-29)20-10-6-18(7-11-20)14-22-4-3-5-23(26(22)31)15-19-8-12-21(13-9-19)25(17-30)28-2/h6-15,24-25,27-30H,3-5,16-17H2,1-2H3/b22-14+,23-15+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.96E+3 | n/a | n/a | n/a | n/a | 7.0 | 20 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
| Assay Description The assay buffer contained 100 mM KHPO4 (pH 7.0), 2 mM EDTA and 2.5 mM reduced GSH. 100 µL of reaction buffer containing human recombinant mPGES... |
Chem Biol Drug Des 83: 670-81 (2014)
Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V |
More data for this Ligand-Target Pair | |
Phospholipase A2
(Homo sapiens (Human)) | BDBM111805
(2,6-Bis[4-(methylaminoethanol)benzylidine] cyclohe...)Show SMILES CNC(CO)c1ccc(\C=C2/CCC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1 Show InChI InChI=1S/C26H32N2O3/c1-27-24(16-29)20-10-6-18(7-11-20)14-22-4-3-5-23(26(22)31)15-19-8-12-21(13-9-19)25(17-30)28-2/h6-15,24-25,27-30H,3-5,16-17H2,1-2H3/b22-14+,23-15+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
| Assay Description Substrate 1,2-bis(heptanoylthio)-glycerophosphocholine and human recombinant PLA2-V were resuspended in assay buffer, and DTNB was dissolved in an aq... |
Chem Biol Drug Des 83: 670-81 (2014)
Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM111805
(2,6-Bis[4-(methylaminoethanol)benzylidine] cyclohe...)Show SMILES CNC(CO)c1ccc(\C=C2/CCC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1 Show InChI InChI=1S/C26H32N2O3/c1-27-24(16-29)20-10-6-18(7-11-20)14-22-4-3-5-23(26(22)31)15-19-8-12-21(13-9-19)25(17-30)28-2/h6-15,24-25,27-30H,3-5,16-17H2,1-2H3/b22-14+,23-15+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.21E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
| Assay Description Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ... |
Chem Biol Drug Des 83: 670-81 (2014)
Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM111805
(2,6-Bis[4-(methylaminoethanol)benzylidine] cyclohe...)Show SMILES CNC(CO)c1ccc(\C=C2/CCC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1 Show InChI InChI=1S/C26H32N2O3/c1-27-24(16-29)20-10-6-18(7-11-20)14-22-4-3-5-23(26(22)31)15-19-8-12-21(13-9-19)25(17-30)28-2/h6-15,24-25,27-30H,3-5,16-17H2,1-2H3/b22-14+,23-15+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.66E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
| Assay Description Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ... |
Chem Biol Drug Des 83: 670-81 (2014)
Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V |
More data for this Ligand-Target Pair | |
Lipoxygenase
(Glycine max (Soybean)) | BDBM111805
(2,6-Bis[4-(methylaminoethanol)benzylidine] cyclohe...)Show SMILES CNC(CO)c1ccc(\C=C2/CCC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1 Show InChI InChI=1S/C26H32N2O3/c1-27-24(16-29)20-10-6-18(7-11-20)14-22-4-3-5-23(26(22)31)15-19-8-12-21(13-9-19)25(17-30)28-2/h6-15,24-25,27-30H,3-5,16-17H2,1-2H3/b22-14+,23-15+ | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.24E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
| Assay Description The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ... |
Chem Biol Drug Des 83: 670-81 (2014)
Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V |
More data for this Ligand-Target Pair | |