Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 411.3 BDBM128257

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM128257 (US8796296, 12) Show SMILES CNc1nc(Nc2cc3OC(C)(C)C(=O)N(C)c3cc2OC)ncc1C(F)(F)F Show InChI InChI=1S/C18H20F3N5O3/c1-17(2)15(27)26(4)11-7-12(28-5)10(6-13(11)29-17)24-16-23-8-9(18(19,20)21)14(22-3)25-16/h6-8H,1-5H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US8796296 (2014) BindingDB Entry DOI: 10.7270/Q28W3C0R
					More data for this Ligand-Target Pair