Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 354.4 BDBM129120

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM129120 (US8802674, 213) Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N(C)C(C)C)ncc1C#N Show InChI InChI=1S/C18H22N6O2/c1-11(2)24(4)17(25)12-6-7-14(15(8-12)26-5)22-18-21-10-13(9-19)16(20-3)23-18/h6-8,10-11H,1-5H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...				US Patent US8802674 (2014) BindingDB Entry DOI: 10.7270/Q2GF0S6N
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