Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
RNA-directed RNA polymerase
(Hepatitis C virus) | BDBM50150371
(CHEMBL84384 | [(2-Chloro-6-methoxy-5-trifluorometh...)Show SMILES COC(=O)N(CC(O)=O)C(=O)c1c(Cl)ccc2c(c(OC)ccc12)C(F)(F)F Show InChI InChI=1S/C17H13ClF3NO6/c1-27-11-6-4-8-9(14(11)17(19,20)21)3-5-10(18)13(8)15(25)22(7-12(23)24)16(26)28-2/h3-6H,7H2,1-2H3,(H,23,24) | PDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase |
Bioorg Med Chem Lett 14: 4221-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.013
BindingDB Entry DOI: 10.7270/Q2MC8ZFF |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50150371
(CHEMBL84384 | [(2-Chloro-6-methoxy-5-trifluorometh...)Show SMILES COC(=O)N(CC(O)=O)C(=O)c1c(Cl)ccc2c(c(OC)ccc12)C(F)(F)F Show InChI InChI=1S/C17H13ClF3NO6/c1-27-11-6-4-8-9(14(11)17(19,20)21)3-5-10(18)13(8)15(25)22(7-12(23)24)16(26)28-2/h3-6H,7H2,1-2H3,(H,23,24) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against calf thymus alpha polymerase |
Bioorg Med Chem Lett 14: 4221-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.013
BindingDB Entry DOI: 10.7270/Q2MC8ZFF |
More data for this
Ligand-Target Pair | |
DNA polymerase beta
(Homo sapiens (Human)) | BDBM50150371
(CHEMBL84384 | [(2-Chloro-6-methoxy-5-trifluorometh...)Show SMILES COC(=O)N(CC(O)=O)C(=O)c1c(Cl)ccc2c(c(OC)ccc12)C(F)(F)F Show InChI InChI=1S/C17H13ClF3NO6/c1-27-11-6-4-8-9(14(11)17(19,20)21)3-5-10(18)13(8)15(25)22(7-12(23)24)16(26)28-2/h3-6H,7H2,1-2H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human beta polymerase |
Bioorg Med Chem Lett 14: 4221-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.013
BindingDB Entry DOI: 10.7270/Q2MC8ZFF |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50150371
(CHEMBL84384 | [(2-Chloro-6-methoxy-5-trifluorometh...)Show SMILES COC(=O)N(CC(O)=O)C(=O)c1c(Cl)ccc2c(c(OC)ccc12)C(F)(F)F Show InChI InChI=1S/C17H13ClF3NO6/c1-27-11-6-4-8-9(14(11)17(19,20)21)3-5-10(18)13(8)15(25)22(7-12(23)24)16(26)28-2/h3-6H,7H2,1-2H3,(H,23,24) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against calf thymus alpha polymerase |
Bioorg Med Chem Lett 14: 4221-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.013
BindingDB Entry DOI: 10.7270/Q2MC8ZFF |
More data for this
Ligand-Target Pair | |