Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359126
(US10220048, Compound AA36 | US10952992, No. AA36 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1sccc1C |r| Show InChI InChI=1S/C27H28N4O6S3/c1-17-12-13-38-24(17)26-29-23(16-39-26)21(14-19-8-10-20(11-9-19)31-40(34,35)36)28-25(32)22(30-27(33)37-2)15-18-6-4-3-5-7-18/h3-13,16,21-22,31H,14-15H2,1-2H3,(H,28,32)(H,30,33)(H,34,35,36)/t21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359126
(US10220048, Compound AA36 | US10952992, No. AA36 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1sccc1C |r| Show InChI InChI=1S/C27H28N4O6S3/c1-17-12-13-38-24(17)26-29-23(16-39-26)21(14-19-8-10-20(11-9-19)31-40(34,35)36)28-25(32)22(30-27(33)37-2)15-18-6-4-3-5-7-18/h3-13,16,21-22,31H,14-15H2,1-2H3,(H,28,32)(H,30,33)(H,34,35,36)/t21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359126
(US10220048, Compound AA36 | US10952992, No. AA36 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1sccc1C |r| Show InChI InChI=1S/C27H28N4O6S3/c1-17-12-13-38-24(17)26-29-23(16-39-26)21(14-19-8-10-20(11-9-19)31-40(34,35)36)28-25(32)22(30-27(33)37-2)15-18-6-4-3-5-7-18/h3-13,16,21-22,31H,14-15H2,1-2H3,(H,28,32)(H,30,33)(H,34,35,36)/t21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359126
(US10220048, Compound AA36 | US10952992, No. AA36 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1sccc1C |r| Show InChI InChI=1S/C27H28N4O6S3/c1-17-12-13-38-24(17)26-29-23(16-39-26)21(14-19-8-10-20(11-9-19)31-40(34,35)36)28-25(32)22(30-27(33)37-2)15-18-6-4-3-5-7-18/h3-13,16,21-22,31H,14-15H2,1-2H3,(H,28,32)(H,30,33)(H,34,35,36)/t21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | <9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |