Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359106
(US10220048, Compound AA16 | US10952992, No. AA16 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CCC(F)(F)F)cs1 |r| Show InChI InChI=1S/C25H27F3N4O6S2/c1-38-24(34)31-20(13-16-5-3-2-4-6-16)22(33)30-21(23-29-19(15-39-23)11-12-25(26,27)28)14-17-7-9-18(10-8-17)32-40(35,36)37/h2-10,15,20-21,32H,11-14H2,1H3,(H,30,33)(H,31,34)(H,35,36,37)/t20-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359106
(US10220048, Compound AA16 | US10952992, No. AA16 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CCC(F)(F)F)cs1 |r| Show InChI InChI=1S/C25H27F3N4O6S2/c1-38-24(34)31-20(13-16-5-3-2-4-6-16)22(33)30-21(23-29-19(15-39-23)11-12-25(26,27)28)14-17-7-9-18(10-8-17)32-40(35,36)37/h2-10,15,20-21,32H,11-14H2,1H3,(H,30,33)(H,31,34)(H,35,36,37)/t20-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359106
(US10220048, Compound AA16 | US10952992, No. AA16 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CCC(F)(F)F)cs1 |r| Show InChI InChI=1S/C25H27F3N4O6S2/c1-38-24(34)31-20(13-16-5-3-2-4-6-16)22(33)30-21(23-29-19(15-39-23)11-12-25(26,27)28)14-17-7-9-18(10-8-17)32-40(35,36)37/h2-10,15,20-21,32H,11-14H2,1H3,(H,30,33)(H,31,34)(H,35,36,37)/t20-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359106
(US10220048, Compound AA16 | US10952992, No. AA16 |...)Show SMILES COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(CCC(F)(F)F)cs1 |r| Show InChI InChI=1S/C25H27F3N4O6S2/c1-38-24(34)31-20(13-16-5-3-2-4-6-16)22(33)30-21(23-29-19(15-39-23)11-12-25(26,27)28)14-17-7-9-18(10-8-17)32-40(35,36)37/h2-10,15,20-21,32H,11-14H2,1H3,(H,30,33)(H,31,34)(H,35,36,37)/t20-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |