Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM193438
(US9199944, 20)Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2nc(Nc3ccc(cc3OC)N3CCN(CC3)C(C)=O)ncc2Cl)c(OC)c1 Show InChI InChI=1S/C30H37ClN8O5/c1-20(40)36-9-11-37(12-10-36)22-6-8-25(27(18-22)43-3)34-29-32-19-23(31)28(35-29)33-24-7-5-21(17-26(24)42-2)38-13-15-39(16-14-38)30(41)44-4/h5-8,17-19H,9-16H2,1-4H3,(H2,32,33,34,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | 25 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
US Patent
| Assay Description
In order to measure the inhibitory activity against ALK, a Grainer 96-well round type bottom plate was added with the compounds (2 μl) prepared ... |
US Patent US9199944 (2015)
BindingDB Entry DOI: 10.7270/Q2J96558 |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor [L1196M]
(Homo sapiens (Human)) | BDBM193438
(US9199944, 20)Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2nc(Nc3ccc(cc3OC)N3CCN(CC3)C(C)=O)ncc2Cl)c(OC)c1 Show InChI InChI=1S/C30H37ClN8O5/c1-20(40)36-9-11-37(12-10-36)22-6-8-25(27(18-22)43-3)34-29-32-19-23(31)28(35-29)33-24-7-5-21(17-26(24)42-2)38-13-15-39(16-14-38)30(41)44-4/h5-8,17-19H,9-16H2,1-4H3,(H2,32,33,34,35) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
US Patent
| Assay Description
In order to measure the inhibitory activity against ALK, a Grainer 96-well round type bottom plate was added with the compounds (2 μl) prepared ... |
US Patent US9199944 (2015)
BindingDB Entry DOI: 10.7270/Q2J96558 |
More data for this
Ligand-Target Pair | |