Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50424429
(CHEMBL2316062)Show SMILES COC(=O)NCCc1c[nH]c2ccc(OCc3ccc(cc3)-c3ccccc3)cc12 Show InChI InChI=1S/C25H24N2O3/c1-29-25(28)26-14-13-21-16-27-24-12-11-22(15-23(21)24)30-17-18-7-9-20(10-8-18)19-5-3-2-4-6-19/h2-12,15-16,27H,13-14,17H2,1H3,(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human LTA4H aminopeptidase activity using Ala-p-nitroanilide as substrate incubated for 2 mins prior to substrate addition measured for... |
Eur J Med Chem 59: 160-7 (2013)
Article DOI: 10.1016/j.ejmech.2012.10.057 BindingDB Entry DOI: 10.7270/Q27P90QH |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50424429
(CHEMBL2316062)Show SMILES COC(=O)NCCc1c[nH]c2ccc(OCc3ccc(cc3)-c3ccccc3)cc12 Show InChI InChI=1S/C25H24N2O3/c1-29-25(28)26-14-13-21-16-27-24-12-11-22(15-23(21)24)30-17-18-7-9-20(10-8-18)19-5-3-2-4-6-19/h2-12,15-16,27H,13-14,17H2,1H3,(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins... |
Eur J Med Chem 59: 160-7 (2013)
Article DOI: 10.1016/j.ejmech.2012.10.057 BindingDB Entry DOI: 10.7270/Q27P90QH |
More data for this Ligand-Target Pair | |
Phospholipase A2, membrane associated
(Homo sapiens (Human)) | BDBM50424429
(CHEMBL2316062)Show SMILES COC(=O)NCCc1c[nH]c2ccc(OCc3ccc(cc3)-c3ccccc3)cc12 Show InChI InChI=1S/C25H24N2O3/c1-29-25(28)26-14-13-21-16-27-24-12-11-22(15-23(21)24)30-17-18-7-9-20(10-8-18)19-5-3-2-4-6-19/h2-12,15-16,27H,13-14,17H2,1H3,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human nonpancreatic secretory phospholipase A2 using 1,2-dimyristoyl-sn-glycero-3-phosphocholine as substrate after 10 mins by spectrop... |
Eur J Med Chem 59: 160-7 (2013)
Article DOI: 10.1016/j.ejmech.2012.10.057 BindingDB Entry DOI: 10.7270/Q27P90QH |
More data for this Ligand-Target Pair | |