Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50424428
(CHEMBL2316063)Show SMILES COC(=O)NCCc1c[nH]c2ccc(OCc3cccc(Oc4ccccc4)c3)cc12 Show InChI InChI=1S/C25H24N2O4/c1-29-25(28)26-13-12-19-16-27-24-11-10-21(15-23(19)24)30-17-18-6-5-9-22(14-18)31-20-7-3-2-4-8-20/h2-11,14-16,27H,12-13,17H2,1H3,(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human LTA4H aminopeptidase activity using Ala-p-nitroanilide as substrate incubated for 2 mins prior to substrate addition measured for... |
Eur J Med Chem 59: 160-7 (2013)
Article DOI: 10.1016/j.ejmech.2012.10.057 BindingDB Entry DOI: 10.7270/Q27P90QH |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50424428
(CHEMBL2316063)Show SMILES COC(=O)NCCc1c[nH]c2ccc(OCc3cccc(Oc4ccccc4)c3)cc12 Show InChI InChI=1S/C25H24N2O4/c1-29-25(28)26-13-12-19-16-27-24-11-10-21(15-23(19)24)30-17-18-6-5-9-22(14-18)31-20-7-3-2-4-8-20/h2-11,14-16,27H,12-13,17H2,1H3,(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins... |
Eur J Med Chem 59: 160-7 (2013)
Article DOI: 10.1016/j.ejmech.2012.10.057 BindingDB Entry DOI: 10.7270/Q27P90QH |
More data for this Ligand-Target Pair | |
Phospholipase A2, membrane associated
(Homo sapiens (Human)) | BDBM50424428
(CHEMBL2316063)Show SMILES COC(=O)NCCc1c[nH]c2ccc(OCc3cccc(Oc4ccccc4)c3)cc12 Show InChI InChI=1S/C25H24N2O4/c1-29-25(28)26-13-12-19-16-27-24-11-10-21(15-23(19)24)30-17-18-6-5-9-22(14-18)31-20-7-3-2-4-8-20/h2-11,14-16,27H,12-13,17H2,1H3,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human nonpancreatic secretory phospholipase A2 using 1,2-dimyristoyl-sn-glycero-3-phosphocholine as substrate after 10 mins by spectrop... |
Eur J Med Chem 59: 160-7 (2013)
Article DOI: 10.1016/j.ejmech.2012.10.057 BindingDB Entry DOI: 10.7270/Q27P90QH |
More data for this Ligand-Target Pair | |