Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 324.1 BDBM50235038

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM50235038 (CHEMBL4102202) Show SMILES COC(=O)c1c(\C(=C/N)C#N)c2ccc(Cl)c(Cl)c2n1C Show InChI InChI=1S/C14H11Cl2N3O2/c1-19-12-8(3-4-9(15)11(12)16)10(7(5-17)6-18)13(19)14(20)21-2/h3-5H,17H2,1-2H3/b7-5-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a
SRI International Curated by ChEMBL					Assay Description Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as MDM2-pre mRNA exon skipping after 4 hrs by luciferase reporter gene a...				Bioorg Med Chem Lett 27: 406-412 (2017) Article DOI: 10.1016/j.bmcl.2016.12.056 BindingDB Entry DOI: 10.7270/Q27946ZF
					More data for this Ligand-Target Pair