Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 545.6 BDBM435374

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM435374 (US10568876, Example 133 | methyl 3-(2-isonicotinoy...) Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1ccncc1 Show InChI InChI=1S/C34H31N3O4/c1-41-34(40)25-9-5-8-24(18-25)27-11-10-26(20-36-32(38)30-19-29(30)22-6-3-2-4-7-22)31-21-37(17-14-28(27)31)33(39)23-12-15-35-16-13-23/h2-13,15-16,18,29-30H,14,17,19-21H2,1H3,(H,36,38)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10568876 (2020) BindingDB Entry DOI: 10.7270/Q22B91FB
					More data for this Ligand-Target Pair