Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 456.5 BDBM360434

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360434 (US9828369, Example 7 | methyl 3-(8-((3-(tert-butyl...) Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2cc(nn2C)C(C)(C)C)c2cnccc12 Show InChI InChI=1S/C27H28N4O3/c1-27(2,3)24-14-23(31(4)30-24)25(32)29-15-19-9-10-20(21-11-12-28-16-22(19)21)17-7-6-8-18(13-17)26(33)34-5/h6-14,16H,15H2,1-5H3,(H,29,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
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