Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM501253
(US11021493, Example 172)Show SMILES COC(C)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1 |r,c:34| Show InChI InChI=1S/C23H28F2N4O4S/c1-14(32-5)12-33-20-11-27-19(10-28-20)18(25)9-15-6-7-17(24)16(8-15)23(4)13-34(30,31)22(2,3)21(26)29-23/h6-11,14H,12-13H2,1-5H3,(H2,26,29)/b18-9-/t14?,23-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM501253
(US11021493, Example 172)Show SMILES COC(C)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1 |r,c:34| Show InChI InChI=1S/C23H28F2N4O4S/c1-14(32-5)12-33-20-11-27-19(10-28-20)18(25)9-15-6-7-17(24)16(8-15)23(4)13-34(30,31)22(2,3)21(26)29-23/h6-11,14H,12-13H2,1-5H3,(H2,26,29)/b18-9-/t14?,23-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM501253
(US11021493, Example 172)Show SMILES COC(C)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1 |r,c:34| Show InChI InChI=1S/C23H28F2N4O4S/c1-14(32-5)12-33-20-11-27-19(10-28-20)18(25)9-15-6-7-17(24)16(8-15)23(4)13-34(30,31)22(2,3)21(26)29-23/h6-11,14H,12-13H2,1-5H3,(H2,26,29)/b18-9-/t14?,23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM501253
(US11021493, Example 172)Show SMILES COC(C)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1 |r,c:34| Show InChI InChI=1S/C23H28F2N4O4S/c1-14(32-5)12-33-20-11-27-19(10-28-20)18(25)9-15-6-7-17(24)16(8-15)23(4)13-34(30,31)22(2,3)21(26)29-23/h6-11,14H,12-13H2,1-5H3,(H2,26,29)/b18-9-/t14?,23-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ... |
US Patent US11021493 (2021)
BindingDB Entry DOI: 10.7270/Q2CZ3B90 |
More data for this
Ligand-Target Pair | |