Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 488.4 BDBM395388

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395388 (US10308636, Example 23-1) Show SMILES COC[C@@]1(CC[C@@H](CC1)Oc1ccc(cc1)-c1ccc(cn1)-c1nc(C)c(n1)C(F)(F)F)C(O)=O |r,wU:6.9,3.2,wD:3.35,(-14.81,-2.24,;-14.04,-3.58,;-12.5,-3.58,;-11.73,-4.91,;-11.73,-6.45,;-10.4,-7.22,;-9.07,-6.45,;-9.07,-4.91,;-10.4,-4.14,;-7.73,-7.22,;-6.4,-6.45,;-6.4,-4.91,;-5.06,-4.14,;-3.73,-4.91,;-3.73,-6.45,;-5.06,-7.22,;-2.4,-4.14,;-2.4,-2.6,;-1.06,-1.83,;.27,-2.6,;.27,-4.14,;-1.06,-4.91,;1.6,-1.83,;3.13,-2.35,;4.01,-1.06,;5.55,-1.02,;3.07,.19,;1.6,-.29,;3.53,1.66,;2.48,2.79,;5.03,1.99,;4.57,.52,;-13.22,-5.31,;-13.62,-6.8,;-14.31,-4.22,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair