Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 476.4 BDBM395371

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395371 (US10308636, Example 57) Show SMILES COC[C@@]1(CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cc1)-c1nnc([nH]1)C(F)(F)F)C(O)=O |r,wU:6.9,3.2,wD:3.34,(-7.7,9.27,;-7.7,7.73,;-9.03,6.96,;-9.03,5.42,;-9.03,3.88,;-7.7,3.11,;-6.36,3.88,;-6.36,5.42,;-7.7,6.19,;-5.03,3.11,;-3.69,3.88,;-3.69,5.42,;-2.36,6.19,;-1.03,5.42,;-1.03,3.88,;-2.36,3.11,;.31,6.19,;1.64,5.42,;2.97,6.19,;2.97,7.73,;1.64,8.5,;.31,7.73,;4.31,8.5,;5.77,8.02,;6.68,9.27,;5.77,10.51,;4.31,10.04,;6.17,12,;5.08,13.09,;7.66,12.4,;7.26,10.91,;-10.36,6.19,;-11.7,5.42,;-10.36,7.73,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair