Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 2
(Homo sapiens (Human)) | BDBM259186
(US9499502, 27bu)Show SMILES COCC1(COC)C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1 |r| Show InChI InChI=1S/C21H23ClN4O5S2/c1-20(11-33(27,28)21(9-29-2,10-30-3)19(23)25-20)17-15(22)8-16(32-17)13-5-4-6-14(7-13)18-26-24-12-31-18/h4-8,12H,9-11H2,1-3H3,(H2,23,25)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 120 | -40.2 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM259186
(US9499502, 27bu)Show SMILES COCC1(COC)C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1 |r| Show InChI InChI=1S/C21H23ClN4O5S2/c1-20(11-33(27,28)21(9-29-2,10-30-3)19(23)25-20)17-15(22)8-16(32-17)13-5-4-6-14(7-13)18-26-24-12-31-18/h4-8,12H,9-11H2,1-3H3,(H2,23,25)/t20-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 1.17E+3 | -34.4 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |