Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 510.3 BDBM300269

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM300269 (US9593110, 18-7) Show SMILES COCc1cc(no1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F Show InChI InChI=1S/C23H22Cl2FN3O5/c1-33-11-16-10-21(29-34-16)22(30)28-15(9-20(27)23(31)32)6-13-3-2-12(7-18(13)25)17-8-14(24)4-5-19(17)26/h2-5,7-8,10,15,20H,6,9,11,27H2,1H3,(H,28,30)(H,31,32)/t15-,20-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
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