Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM376967
(US10329300, Example 55 | US11696917, Example 55 | ...)Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1Cl Show InChI InChI=1S/C24H27ClN8O4/c1-5-16(34)32-9-8-14(11-32)33-23-18(22(26)27-12-28-23)20(30-33)24(36)29-15-7-6-13(10-17(35)31(2)3)19(25)21(15)37-4/h5-7,12,14H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F193VV |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM376967
(US10329300, Example 55 | US11696917, Example 55 | ...)Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1Cl Show InChI InChI=1S/C24H27ClN8O4/c1-5-16(34)32-9-8-14(11-32)33-23-18(22(26)27-12-28-23)20(30-33)24(36)29-15-7-6-13(10-17(35)31(2)3)19(25)21(15)37-4/h5-7,12,14H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
TAIHO PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile... |
US Patent US10329300 (2019)
BindingDB Entry DOI: 10.7270/Q2MG7RWF |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM376967
(US10329300, Example 55 | US11696917, Example 55 | ...)Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1Cl Show InChI InChI=1S/C24H27ClN8O4/c1-5-16(34)32-9-8-14(11-32)33-23-18(22(26)27-12-28-23)20(30-33)24(36)29-15-7-6-13(10-17(35)31(2)3)19(25)21(15)37-4/h5-7,12,14H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Paris 7-Denis Diderot
| Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime... |
Bioorg Med Chem 16: 1242-53 (2008)
BindingDB Entry DOI: 10.7270/Q2BR8VHD |
More data for this
Ligand-Target Pair | |