Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50528199
(CHEMBL4456061)Show SMILES COc1c(csc1C(N)=O)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C22H24N4O2S/c1-14-17(15-3-5-16(6-4-15)26-9-7-24-8-10-26)11-25-12-18(14)19-13-29-21(22(23)27)20(19)28-2/h3-6,11-13,24H,7-10H2,1-2H3,(H2,23,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 712 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395
BindingDB Entry DOI: 10.7270/Q2MK6HB1 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50528199
(CHEMBL4456061)Show SMILES COc1c(csc1C(N)=O)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C22H24N4O2S/c1-14-17(15-3-5-16(6-4-15)26-9-7-24-8-10-26)11-25-12-18(14)19-13-29-21(22(23)27)20(19)28-2/h3-6,11-13,24H,7-10H2,1-2H3,(H2,23,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substr... |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395
BindingDB Entry DOI: 10.7270/Q2MK6HB1 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50528199
(CHEMBL4456061)Show SMILES COc1c(csc1C(N)=O)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C22H24N4O2S/c1-14-17(15-3-5-16(6-4-15)26-9-7-24-8-10-26)11-25-12-18(14)19-13-29-21(22(23)27)20(19)28-2/h3-6,11-13,24H,7-10H2,1-2H3,(H2,23,27) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of ALK5 (unknown origin) expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter measured after 24 hrs ... |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395
BindingDB Entry DOI: 10.7270/Q2MK6HB1 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50528199
(CHEMBL4456061)Show SMILES COc1c(csc1C(N)=O)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C22H24N4O2S/c1-14-17(15-3-5-16(6-4-15)26-9-7-24-8-10-26)11-25-12-18(14)19-13-29-21(22(23)27)20(19)28-2/h3-6,11-13,24H,7-10H2,1-2H3,(H2,23,27) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395
BindingDB Entry DOI: 10.7270/Q2MK6HB1 |
More data for this
Ligand-Target Pair | |